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Table 1 summarizes key studies that elucidate the involvement of mtDNA in mediating neuroinflammatory responses in PD

In addition, activated T cells express CD40L, which can activate the CD40 receptor expressed by B cells and by monocytes/macrophages

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Ethics declarations Ethical approval Human scalp tissue was obtained with approval from the Global Medical Research Center Institutional Review Board (IRB No

In brief, metabolites were extracted, resuspended in required solvents (50% methanol for TCA cycle intermediates and water for sugar phosphates) and separated on a Synergi 4-m Fusion-RP 80 LC column (100 4.6 mm, Phenomenex) using a Shimadzu Nexera UHPLC system